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Involvement of miR-199a-3p/DDR1 in vascular endothelial cell senescence in diabetes

Involvement of miR-199a-3p/DDR1 in vascular endothelial cell senescence in diabetes

Posted on July 24, 2021July 24, 2021 by Andres
Endothelial cell dysfunction is a outstanding function of diabetic cardiovascular issues, and endothelial cell senescence is taken into account to be an vital contributor to endothelial dysfunction. Discoidin area receptor 1 (DDR1) has been reported to be concerned in atherogenesis and cerebral ischemia/reperfusion damage. In this examine, we aimed to discover the function of DDR1 in endothelial cell senescence underneath diabetic situations and elucidate the underlying mechanisms.
A diabetic rat mannequin was established by a single intraperitoneal injection of streptozocin (STZ) (60 mg/kg), which confirmed a rise in senescence-associated β-galactosidase (SA-β-gal) staining sign of thoracic aortic endothelium, impaired vascular construction and performance, accompanied by an up-regulation of DDR1. Next, we verified the function of DDR1 in endothelial senescence and the underlying mechanisms in excessive glucose-treated human umbilical vein endothelial cells (HUVECs).
Consistent with the in vivo findings, excessive glucose induced endothelial senescence, impaired endothelial operate and elevated DDR1 expression, accompanied by the elevation of senescence-related genes p53 and p21 expression, and these results have been reversed by DDR1 siRNA. DDR1 has been documented to be a possible goal of miR-199a-3p.
Here, we discovered that miR-199a-3p was down-regulated by excessive glucose in the aorta tissue and HUVECs, whereas miR-199a-3p mimic considerably suppressed elevated endothelial senescence and elevated DDR1 induced by excessive glucose.
In conclusion, our information demonstrated that miR-199a-3p/DDR1/p53/p21 signaling pathway was concerned in endothelial senescence underneath diabetic situations, and therapeutic concentrating on DDR1 could be exploited to inhibit endothelial senescence owing to excessive glucose publicity.

Study of blood glucose and insulin infusion charge in real-time in diabetic rats utilizing a synthetic pancreas system

Artificial pancreas system (APS) is an rising new therapy for kind 1 diabetes mellitus. The intention of this examine was to develop a rat APS as a analysis software and show its software. We established a rat APS utilizing Medtronic Minimed Pump 722, Medtronic Enlite sensor, and the open synthetic pancreas system as a controller.
We examined totally different dilutions of Humalog (100 items/ml) in saline ranged from 1:Three to 1:20 and decided that 1:7 dilution works effectively for rats with ~500g body weight. Blood glucose ranges (BGL) of diabetic rats fed with chow food plan (58% carbohydrate) whose BGL was managed by the closed-loop APS for the overall period of 207h have been in euglycemic vary (70-180 mg/dl) for 94.5% of the time with 2.1% and three.4% for hyperglycemia (>180mg/dl) and hypoglycemia (<70 mg/dl), respectively.
Diabetic rats fed with Sucrose pellets (94.8% carbohydrate) for the experimental period of 175h have been in euglycemic vary for 61% of the time with 35% and 4% for hyperglycemia and hypoglycemia, respectively. Heathy rats fed with chow food plan confirmed nearly a straight line of BGL ~ 95 mg/dl (common 94.Eight mg/dl) throughout the complete experimental interval (281h), which was minimally altered by meals consumption.
In the wholesome rats, feeding sucrose pellets induced larger vary of BGL in excessive and low ranges however nonetheless inside euglycemic vary (99.9%). Next, to check how wholesome and diabetic rats deal with supra-physiological concentrations of glucose, we intraperitoneally injected varied quantities of 50% dextrose (2, 3, 4g/kg) and monitored BGL.
Involvement of miR-199a-3p/DDR1 in vascular endothelial cell senescence in diabetes
Duration of hyperglycemia after injection of 50% dextrose in any respect three totally different concentrations was considerably larger for wholesome rats than diabetic rats, suggesting that insulin infusion by APS was superior in decreasing BGL as in comparison with pure insulin launched from pancreatic β-cells. Ex vivo research confirmed that islets remoted from diabetic rats have been nearly fully devoid of pancreatic β-cells however with intact α-cells as anticipated.
Lipid droplet deposition in the liver of diabetic rats was considerably decrease with greater ranges of triacylglyceride in the blood as in comparison with these of wholesome rats, suggesting lipid metabolism was altered in diabetic rats. However, glycogen storage in the liver decided by Periodic acid-Schiff staining was not altered in diabetic rats as in comparison with wholesome rats.
A rat APS could also be used as a strong software not solely to check alterations of glucose and insulin homeostasis in real-time attributable to food plan, train, hormones, or antidiabetic brokers, but in addition to check mathematical and engineering fashions of blood glucose prediction or new algorithms for closed-loop APS.

A evaluate on community pharmacology based mostly phytotherapy in treating diabetes– An environmental perspective

Diabetes has grow to be frequent life-style dysfunction related to weight problems and cardiovascular ailments. Environmental components like bodily inactivity, polluted environment and unhealthy weight-reduction plan additionally performs an important function in diabetes pathogenesis.
As the present anti-diabetic medicine possess unprecedented unintended effects, conventional natural drugs can be utilized another remedy. The paramount problem with the natural formulation utilization is the dearth of standardized process, entangled with little data on drug security and mechanism of drug motion. Heavy metallic contamination is a significant environmental hazard the place crops are likely to accumulate poisonous metals like nickel, chromium and lead by industrial and agricultural actions.
It turns into inappropriate to make use of these crops for phytotherapy as it could have an effect on the human well being on long run consumption. This evaluate focus on concerning the environmental threat components associated to diabetes and higher implication of medicinal crops in anti-diabetic remedy utilizing community pharmacology. It is an in silico analytical software that helps to unravel the multi-targeted motion of natural formulations wealthy in secondary metabolites.

ExoStd? Lyophilized Exosome Standard (30 µg, U87 MG, 2 vials)

M1054-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, U87 MG, 2 vials)

M1055-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, COLO1 cell line, 2 vials)

M1048-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, COLO1 cell line, 2 vials)

M1049-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, MM1 cell line, 2 vials)

M1050-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, MM1 cell line, 2 vials)

M1051-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, BLCL21 cell line, 2 vials)

M1052-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, BLCL21 cell line, 2 vials)

M1053-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, HCT116 cell line, 2 vials)

M1058-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, HCT116 cell line, 2 vials)

M1059-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, PC3 cell line, 2 vials)

M1060-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, PC3 cell line, 2 vials)

M1061-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, DAUD1 cell line, 2 vials)

M1064-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, DAUD1 cell line, 2 vials)

M1065-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, A549 cell line, 2 vials)

M1066-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, A549 cell line, 2 vials)

M1067-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, B16F10 cell line, 2 vials)

M1070-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, B16F10 cell line, 2 vials)

M1071-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, BPH-1 cell line, 2 vials)

M1062-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, BPH-1 cell line, 2 vials)

M1063-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, K-562 cell line, 2 vials)

M1068-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, K-562 cell line, 2 vials)

M1069-2 Biovision each 861.6 EUR

ExoStd? Lyophilized Exosome Standard (30 µg, SK-N-SH cell line, 2 vials)

M1056-2 Biovision each 724.8 EUR

ExoStd? Lyophilized Exosome Standard (100 µg, SK-N-SH cell line, 2 vials)

M1057-2 Biovision each 861.6 EUR

SARS-CoV-2 Nucleocapsid Protein, Avi-His-tag

E80027 EpiGentek
  • 635.80 EUR
  • 4087.60 EUR
  • 1 ml
  • 100 ul

Recombinant SARS-CoV-2 Spike Glycoprotein(S) (D614G), Partial

E80028 EpiGentek
  • 388.30 EUR
  • 860.20 EUR
  • 20 ul
  • 100 ul

SARS-CoV-2 Spike S1 RBD Protein, Avi-His-tag

E80024 EpiGentek
  • 635.80 EUR
  • 4995.10 EUR
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion

E80026 EpiGentek
  • 588.50 EUR
  • 823.90 EUR
  • 20 ul
  • 50 ul

SARS-CoV-2 Spike S1 (16-685) Protein, Avi-His-tag

E80021 EpiGentek
  • 635.80 EUR
  • 4276.80 EUR
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 RBD (V367F) Protein, Avi-His-tag

E80023 EpiGentek
  • 635.80 EUR
  • 3934.70 EUR
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 (13-665) Protein, Fc Fusion, Avi-tag

E80020 EpiGentek
  • 635.80 EUR
  • 4276.80 EUR
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 (16-685) Protein, Fc Fusion, Avi-tag

E80022 EpiGentek
  • 635.80 EUR
  • 4276.80 EUR
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag

E80025 EpiGentek
  • 635.80 EUR
  • 3934.70 EUR
  • 100 ul
  • 1 ml

Exosome Component 2 (EXOSC2) Antibody

20-abx172308 Abbexa
  • 1028.40 EUR
  • 526.80 EUR
  • 1 mg
  • 200 ug

Exosome Component 2 (EXOSC2) Antibody

20-abx125830 Abbexa
  • 493.20 EUR
  • 710.40 EUR
  • 218.40 EUR
  • 376.80 EUR
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Exosome Component 2 (EXOSC2) Antibody

20-abx112411 Abbexa
  • 878.40 EUR
  • 477.60 EUR
  • 150 ul
  • 50 ul

Exosome Component 2 (EXOSC2) Antibody

20-abx003412 Abbexa
  • 493.20 EUR
  • 710.40 EUR
  • 100 ul
  • 200 ul

Exosome Component 2 (EXOSC2) Antibody

abx034983-400ul Abbexa 400 ul 627.6 EUR

Exosome Component 2 (EXOSC2) Antibody

abx034983-80l Abbexa 80 µl 343.2 EUR

Exosome Component 2 (EXOSC2) Antibody

abx232901-100ug Abbexa 100 ug 577.2 EUR

Exosome Component 2 (EXOSC2) Antibody

abx232902-100ug Abbexa 100 ug 661.2 EUR

Exosome Component 2 (EXOSC2) Antibody

20-abx176346 Abbexa
  • 510.00 EUR
  • 159.60 EUR
  • 1446.00 EUR
  • 693.60 EUR
  • 393.60 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant Transmembrane Protease Serine 2 Protein, Partial

E80016 EpiGentek
  • 470.80 EUR
  • 753.50 EUR
  • 1824.90 EUR
  • 20 ul
  • 100 ul
  • 500 ul

TNFR2 Tumor Necrosis Factor Receptor Type 2 Human Recombinant Protein

PROTP20333-2 BosterBio Regular: 20ug 380.4 EUR
Description: TNFR2 Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 20kDa. The TNFR2 is purified by proprietary chromatographic techniques.

Human Exosome Component 2 (EXOSC2) Protein

20-abx653328 Abbexa
  • 693.60 EUR
  • 309.60 EUR
  • 2064.00 EUR
  • 828.00 EUR
  • 510.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Exosome Component 2 (EXOSC2) ELISA Kit

DLR-EXOSC2-Hu-48T DL Develop 48T 620.4 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human Exosome Component 2 (EXOSC2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Exosome Component 2 (EXOSC2) ELISA Kit

DLR-EXOSC2-Hu-96T DL Develop 96T 807.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human Exosome Component 2 (EXOSC2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Exosome Component 2 (EXOSC2)ELISA Kit

201-12-2689 SunredBio 96 tests 528 EUR
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Exosome Component 2 (EXOSC2) ELISA Kit

20-abx151457 Abbexa
  • 8853.60 EUR
  • 4719.60 EUR
  • 1093.20 EUR
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Exosome Component 2 (EXOSC2) CLIA Kit

20-abx495555 Abbexa
  • 9567.60 EUR
  • 5095.20 EUR
  • 1177.20 EUR
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human)

4-PAH822Hu01 Cloud-Clone
  • 296.40 EUR
  • 3012.00 EUR
  • 750.00 EUR
  • 372.00 EUR
  • 256.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2)

Human Exosome Component 2(EXOSC2)ELISA Kit

QY-E01130 Qayee Biotechnology 96T 433.2 EUR

Human Exosome Component 2 (EXOSC2) ELISA Kit

RD-EXOSC2-Hu-48Tests Reddot Biotech 48 Tests 625.2 EUR

Human Exosome Component 2 (EXOSC2) ELISA Kit

RD-EXOSC2-Hu-96Tests Reddot Biotech 96 Tests 867.6 EUR

Human Exosome Component 2 (EXOSC2) ELISA Kit

RDR-EXOSC2-Hu-48Tests Reddot Biotech 48 Tests 652.8 EUR

Human Exosome Component 2 (EXOSC2) ELISA Kit

RDR-EXOSC2-Hu-96Tests Reddot Biotech 96 Tests 907.2 EUR

Human Exosome Component 2 (EXOSC2) ELISA Kit

SEH822Hu-10x96wellstestplate Cloud-Clone 10x96-wells test plate 5677.8 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exosome Component 2 (EXOSC2) in Tissue homogenates, cell lysates and other biological fluids.

Human Exosome Component 2 (EXOSC2) ELISA Kit

SEH822Hu-1x48wellstestplate Cloud-Clone 1x48-wells test plate 572.76 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exosome Component 2 (EXOSC2) in Tissue homogenates, cell lysates and other biological fluids.

Human Exosome Component 2 (EXOSC2) ELISA Kit

SEH822Hu-1x96wellstestplate Cloud-Clone 1x96-wells test plate 766.8 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exosome Component 2 (EXOSC2) in Tissue homogenates, cell lysates and other biological fluids.

Human Exosome Component 2 (EXOSC2) ELISA Kit

SEH822Hu-5x96wellstestplate Cloud-Clone 5x96-wells test plate 3090.6 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exosome Component 2 (EXOSC2) in Tissue homogenates, cell lysates and other biological fluids.

Human Exosome Component 2 (EXOSC2) ELISA Kit

4-SEH822Hu Cloud-Clone
  • 5738.40 EUR
  • 3031.20 EUR
  • 768.00 EUR
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Exosome Component 2 (EXOSC2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Exosome Component 2 ELISA Kit (EXOSC2)

RK01330 Abclonal 96 Tests 625.2 EUR

Human Exosome Component 2 (EXOSC2)ELISA Kit

YLA3329HU-48T Shanghai YL Biotech 48T 435 EUR

Human Exosome Component 2 (EXOSC2)ELISA Kit

YLA3329HU-96T Shanghai YL Biotech 96T 562.5 EUR

Lyophilized Exosome Standards

ExoA375 ImmunoStep 100 μg 364.2 EUR

Lyophilized Exosome Standards

ExoHT29 ImmunoStep 100 μg 364.2 EUR

Lyophilized Exosome Standards

ExoMCF7 ImmunoStep 100 μg 364.2 EUR

Lyophilized Exosome Standards

ExoPC3 ImmunoStep 100 μg 364.2 EUR

Lyophilized Exosome Standards

ExoPLASMA ImmunoStep 100 μg 364.2 EUR

Lyophilized Exosome Standards

ExoUrine ImmunoStep 100 μg 364.2 EUR

Exosome precipitation Solution

EPStep ImmunoStep 12 ml 333 EUR

ACE2, His-Tag Protein

E80019 EpiGentek
  • 612.70 EUR
  • 1437.70 EUR
  • 20 ul
  • 100 ul

2-Methoxyestradiol (2-MeOE2)

27762-2 BPS Bioscience 100 mg 230 EUR
Description: 2-Methoxyestradiol (2-MeOE2), an endogenous metabolite of 17β-estradiol (E2), is an inhibitor of microtubule assembly that inhibits the polymerization of tubulin and interferes with mitotic spindle dynamics leading to the blockage of mitosis of human cancer cells which lack estrogen receptors in metaphase. 2-MeOE2 is also an inhibitor of tumor growth and angiogenesis. Study results have shown that 2-MeOE2 induces mammalian cell transformation and genotoxicity in Syrian hamster embryo (SHE) fibroblasts through concentration-dependent inhibition of cell growth. Moreover, 2-MeOE2 has demonstrated anti-proliferative activity against estrogen-responsive breast cancer cell line MCF-7 and subsequent inhibition of the growth of tumors subcutaneously inoculated in mice.

ELISA kit for Human EXOSC2 (Exosome Component 2)

ELK4639 ELK Biotech 1 plate of 96 wells 518.4 EUR
Description: A sandwich ELISA kit for detection of Exosome Component 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human), APC

4-PAH822Hu01-APC Cloud-Clone
  • 414.00 EUR
  • 3930.00 EUR
  • 1094.40 EUR
  • 528.00 EUR
  • 262.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2). This antibody is labeled with APC.

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human), Biotinylated

4-PAH822Hu01-Biotin Cloud-Clone
  • 373.20 EUR
  • 2952.00 EUR
  • 872.40 EUR
  • 457.20 EUR
  • 262.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2). This antibody is labeled with Biotin.

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human), Cy3

4-PAH822Hu01-Cy3 Cloud-Clone
  • 502.80 EUR
  • 5190.00 EUR
  • 1410.00 EUR
  • 654.00 EUR
  • 301.20 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2). This antibody is labeled with Cy3.

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human), FITC

4-PAH822Hu01-FITC Cloud-Clone
  • 355.20 EUR
  • 3168.00 EUR
  • 900.00 EUR
  • 446.40 EUR
  • 234.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2). This antibody is labeled with FITC.

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human), HRP

4-PAH822Hu01-HRP Cloud-Clone
  • 379.20 EUR
  • 3426.00 EUR
  • 968.40 EUR
  • 477.60 EUR
  • 247.20 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2). This antibody is labeled with HRP.

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human), PE

4-PAH822Hu01-PE Cloud-Clone
  • 355.20 EUR
  • 3168.00 EUR
  • 900.00 EUR
  • 446.40 EUR
  • 234.00 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2). This antibody is labeled with PE.

XStamp IL2 exosome IL-2 receptor targeting lentivector

XSTP726PA-1 SBI 10 ug 991.2 EUR

FluoroCet Exosome Quantitation Kit

FCET96A-1 SBI 96 reactions 871.2 EUR

Fluorescent Exosome Standard (Urine )

ESF-15 Creative Biolabs 100 µg 2067.6 EUR
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

EXOCET Exosome Quantitation Kit

EXOCET96A-1 SBI 96 reactions 625.2 EUR

Exosome Component 9 Peptide

46-967P ProSci 0.1 mg 405.6 EUR
Description: (CT) PMSCL1 Peptide

Exosome Component 5 Protein

20-abx260873 Abbexa
  • 4101.60 EUR
  • 393.60 EUR
  • 276.00 EUR
  • 1 mg
  • 25 ug
  • 5 ug

Exosome Component 7 Protein

20-abx261347 Abbexa
  • 4101.60 EUR
  • 393.60 EUR
  • 276.00 EUR
  • 1 mg
  • 20 ug
  • 5 ug

Exosome Component 10 Protein

20-abx261805 Abbexa
  • 5238.00 EUR
  • 393.60 EUR
  • 276.00 EUR
  • 1 mg
  • 20 ug
  • 5 ug

Exosome Component 4 Protein

20-abx261954 Abbexa
  • 5388.00 EUR
  • 393.60 EUR
  • 276.00 EUR
  • 1 mg
  • 20 ug
  • 5 ug

Exosome Component 9 Protein

20-abx262123 Abbexa
  • 393.60 EUR
  • 6106.80 EUR
  • 276.00 EUR
  • 10 ug
  • 1 mg
  • 2 µg

Exosome Component 8 Protein

20-abx262850 Abbexa
  • 393.60 EUR
  • 7676.40 EUR
  • 276.00 EUR
  • 10 ug
  • 1 mg
  • 2 µg

Exosome Component 3 Protein

20-abx263422 Abbexa
  • 276.00 EUR
  • 1930.80 EUR
  • 393.60 EUR
  • 1 µg
  • 50 ug
  • 5 ug

Exosome Component 1 Protein

20-abx263423 Abbexa
  • 1930.80 EUR
  • 393.60 EUR
  • 276.00 EUR
  • 100 ug
  • 10 ug
  • 2 µg

Nori® Human Angiopoietin-2 (ANG-2) ELISA Kit (2 plates)

GR106245-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori Equine MMP-2/TIMP-2 Complex ELISA Kit (2 plates)

GR106502-2 Genorise Scientific 2 x 96-well 998.4 EUR

2-Propyl-β-D-glucuronide, 2 mg

0904-2 AthenaES 2 mg 194.4 EUR

BNP Human, B-type Natriuretic Peptide Human Recombinant Protein, His Tag

PROTP16860-2 BosterBio Regular: 10ug 380.4 EUR
Description: BNP Recombinant Human fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids (27-134 a.a) and having a molecular mass of 14 kDa.                   

Exosome Component 2 (EXOSC2) Polyclonal Antibody (Human), APC-Cy7

4-PAH822Hu01-APC-Cy7 Cloud-Clone
  • 685.20 EUR
  • 7716.00 EUR
  • 2046.00 EUR
  • 912.00 EUR
  • 382.80 EUR
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Exosome Component 2 (EXOSC2). This antibody is labeled with APC-Cy7.

Nori® Human MMP-2/TIMP-2 Complex ELISA Kit (2 plates)

GR106372-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Human b-defensin 2 (BD-2) ELISA Kit- 2 Plates

GR111099-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori Equine MMP-2 ELISA Kit-2 Plates

GR106478-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori Equine TIM-2 ELISA Kit (2 plates)

GR106516-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori Human TIM-2 ELISA Kit-2 Plates

GR111039-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori Canine TIM-2 ELISA Kit (2 plates)

GR115041-2 Genorise Scientific 2 x 96-well 998.4 EUR

Monoclonal Anti-Dengue Virus Type 1-4 (pan, NS1) IgG, clone 2 (pairs with clone 1)

AB-21122-2 Alpha Diagnostics 0.5 ml 634.8 EUR

2 M NaCl

GR103063-2 Genorise Scientific 200 mL 70.8 EUR

Thaw Medium 2

60184-2 BPS Bioscience 500 ml 675 EUR
Description: This liquid Cell Thawing Medium is optimized for thawing and plating select BPS Bioscience cell lines, including_x000D__x000D_• PD-1/NFAT Reporter-Jurkat cell #60535_x000D__x000D_• NFAT Reporter (Luc) - Jurkat Cell Line #60621_x000D__x000D_• NF-ĸB-Luciferase Reporter (Luc) - Jurkat Cell Line #60651_x000D__x000D_• ADCC Bioassay Effector Cell F variant (Low Affinity) #60540_x000D__x000D_• ADCC Bioassay Effector Cell V variant (High Affinity) #60541_x000D__x000D_Note: once cells are well-established, switch to the appropriate cell growth medium.

Apoptosis Activator 2

27733-2 BPS Bioscience 50 mg 390 EUR
Description: Apoptosis Activator 2 is a small, cell permeable activator of caspase-3. Apoptosis Activator 2 induces apoptosis specifically in tumor cell lines, but not normal cell lines, with IC50 value of about 4 µM.

Recombinant TMPRSS2 Protein, Partial

E80017 EpiGentek
  • 423.50 EUR
  • 660.00 EUR
  • 2321.00 EUR
  • 20 ul
  • 100 ul
  • 1 ml

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial

E80018 EpiGentek
  • 388.30 EUR
  • 860.20 EUR
  • 4888.40 EUR
  • 20 ul
  • 100 ul
  • 1 ml

HPV type 2

DAG4703 Creative Diagnostics 0.25 mg 864 EUR

HPV type 2

DAG206 Creative Diagnostics 1 ml 1057.2 EUR

Nori® Chicken Netrin-2 ELISA Kit (2 plates)

GR106184-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Human Tie-2 ELISA Kit (2 plates)

GR106458-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Human TIMP-2 ELISA Kit (2 plates)

GR106460-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Human Trappin-2 ELISA Kit (2 plates)

GR106467-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Rabbit IL-2 ELISA Kit- 2 Plates

GR144032-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Monkey IL-2 ELISA Kit- 2 Plates

GR169004-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Donkey IL-2 ELISA Kit- 2 Plates

GR170004-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Porcine MMP-2 ELISA Kit- 2 Plates

GR113006-2 Genorise Scientific 2 x 96-well 998.4 EUR

Nori® Chicken MMP-2 ELISA Kit- 2 Plates

GR114008-2 Genorise Scientific 2 x 96-well 998.4 EUR
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Also, a particular focus is tried to pool the databases concerning the medicinal crops for diabetes and related ailments, their bioactive compounds, attainable diabetic targets, drug-target interplay and toxicology experiences which will open an aisle in safer, efficient and toxicity-free drug discovery.

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  • Compare Appoptosis lab reagents for research
  • Compare ELISA lab reagents for research
  • Treating Diabetes Utilizing a Low Carbohydrate Ketogenic Diet and Intermittent Fasting Without Significant Weight Loss: A Case Report
  • Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis
  • The Effect of Integrated Intervention Based on Protection Motivation Theory and Implementation Intention to Promote Physical Activity and Physiological Indicators of Patients with Type 2 Diabetes

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  • blood
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  • elektroporation
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  • Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease.
  • Prospect of Sodium-Glucose Co-transporter 2 Inhibitors Combined With Insulin for the Treatment of Type 2 Diabetes.
  • protein
  • Rabbit
  • Rat
  • rna
  • Salmonella
  • Sheep
  • step
  • sterile
  • The Cost-Effectiveness of Lifestyle Interventions for Preventing Diabetes in a Health Resource-Limited Setting.
  • The Need for Diabetes Care Customization in the ICU at the Time of SARS-CoV-2 Outbreak.
  • Torpedo
  • Trout
  • Yeast
  • blood
  • Blot
  • cDNA
  • ChiP
  • coli recombinant
  • colorimetric
  • Control
  • dna
  • Effects of Laser Acupuncture and Dietary Intervention on Key Obesity Parameters.
  • elektroporation
  • elisa
  • Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease.
  • Prospect of Sodium-Glucose Co-transporter 2 Inhibitors Combined With Insulin for the Treatment of Type 2 Diabetes.
  • protein
  • Rabbit
  • Rat
  • rna
  • Salmonella
  • Sheep
  • step
  • sterile
  • The Cost-Effectiveness of Lifestyle Interventions for Preventing Diabetes in a Health Resource-Limited Setting.
  • The Need for Diabetes Care Customization in the ICU at the Time of SARS-CoV-2 Outbreak.
  • Torpedo
  • Trout
  • Yeast
  • Compare Appoptosis lab reagents for research
  • Compare ELISA lab reagents for research
  • Treating Diabetes Utilizing a Low Carbohydrate Ketogenic Diet and Intermittent Fasting Without Significant Weight Loss: A Case Report
  • Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis
  • The Effect of Integrated Intervention Based on Protection Motivation Theory and Implementation Intention to Promote Physical Activity and Physiological Indicators of Patients with Type 2 Diabetes
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